Article

FTO separation-of-function mutations alter m <sup>6</sup> A versus m <sup>6</sup> A <sub>m</sub> demethylation selectivity on RNA

2026-05-19

Abstract excerpt

<h4>ABSTRACT</h4> The RNA demethylase FTO erases N6-methyladenosine (m 6 A) and cap-associated N6,2′-O-dimethyladenosine (m 6 A m ) modifications. However, the molecular basis of its substrate selectivity and the biological effects of m 6 A versus m 6 A m demethylation in cells remain poorly understood. Here we report two engineered FTO separation-of-function mutants to selectively demethylate either m 6 A...

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Literature Corpus work: e115dd5f-2413-5bcd-92b4-941ea4e72cd9
DOI: 10.64898/2026.05.19.726201

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FTO separation-of-function mutations alter m <sup>6</sup> A versus m <sup>6</sup> A <sub>m</sub> demethylation selectivity on RNADOI 10.64898/2026.05.19.726201Read

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