Article
CTCFL expression is associated with cerebral vascular abnormalities.
Tissue & cell - 1 Oct 2021
Sati Leyla, Soygur Bikem, Goksu Ethem, Bassorgun Cumhur Ibrahim, McGrath James
Abstract excerpt
CTCFL is expressed in testis, oocytes and embryonic stem cells, and is aberrantly expressed in malignant cells, and is classified as a cancer-testis gene. We have previously shown by using a tetracycline-inducible Ctcfl transgene that inappropriate expression of Ctcfl negatively impacts fetal development and causes early postnatal lethality in the mouse. The affected pups displayed severe vascular abnormalities...
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