Article
Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling.
Proceedings of the National Academy of Sciences of the United States of America - 13 Jul 2010
Wüstehube Joycelyn, Bartol Arne, Liebler Sven S, Brütsch René, Zhu Yuan, Felbor Ute, Sure Ulrich, Augustin Hellmut G, Fischer Andreas
Abstract excerpt
Cerebral cavernous malformations (CCM) are frequent vascular abnormalities caused by mutations in one of the CCM genes. CCM1 (also known as KRIT1) stabilizes endothelial junctions and is essential for vascular morphogenesis in mouse embryos. However, cellular functions of CCM1 during the early st...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Calcium-Binding Proteins
- Capillaries
- Endothelial Cells
- Female
- Hemangioma, Cavernous, Central Nervous System
- Humans
- Intercellular Signaling Peptides and Proteins
- Mice
- Mice, SCID
- Microvessels
- Mitogen-Activated Protein Kinases