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Article

Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling.

Proceedings of the National Academy of Sciences of the United States of America - 13 Jul 2010

Wüstehube Joycelyn, Bartol Arne, Liebler Sven S, Brütsch René, Zhu Yuan, Felbor Ute, Sure Ulrich, Augustin Hellmut G, Fischer Andreas

Abstract excerpt

Cerebral cavernous malformations (CCM) are frequent vascular abnormalities caused by mutations in one of the CCM genes. CCM1 (also known as KRIT1) stabilizes endothelial junctions and is essential for vascular morphogenesis in mouse embryos. However, cellular functions of CCM1 during the early steps of the CCM pathogenesis remain unknown. We show here that CCM1 represents an antiangiogenic protein to keep the...

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Identifiers

PMID: 20616044
DOI: 10.1073/pnas.1000132107
PMCID: PMC2906569

Genes

DLL4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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