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Article

Cerebral cavernous malformations: from genes to proteins to disease.

Journal of neurosurgery - 1 Jan 2012

Cavalcanti Daniel D, Kalani M Yashar S, Martirosyan Nikolay L, Eales Justin, Spetzler Robert F, Preul Mark C

Abstract excerpt

Over the past half century molecular biology has led to great advances in our understanding of angio- and vasculogenesis and in the treatment of malformations resulting from these processes gone awry. Given their sporadic and familial distribution, their developmental and pathological link to capillary telangiectasias, and their observed chromosomal abnormalities, cerebral cavernous malformations (CCMs) are...

Topics

Genetic Loci
Hemangioma, Cavernous, Central Nervous System
Humans
Mutation
Neovascularization, Pathologic
Signal Transduction

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 21962164
DOI: 10.3171/2011.8.JNS101241

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21962164-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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