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Article

Molecular Signatures of Chromosomal Instability Correlate With Copy Number Variation Patterns and Patient Outcome in IDH-Mutant and IDH-Wildtype Astrocytomas.

Journal of neuropathology and experimental neurology - 22 Mar 2021

Richardson Timothy E, Sathe Adwait Amod, Xing Chao, Mirchia Kanish, Viapiano Mariano S, Snuderl Matija, Abdullah Kalil G, Hatanpaa Kimmo J, Walker Jamie M

Abstract excerpt

Chromosomal instability due to mutations in genes guarding the stability of the genome is a well-known mechanism underlying tumorigenesis and malignant progression in numerous cancers. The effect of this process in gliomas is mostly unknown with relatively little research examining the effects of chromosomal instability on patient outcome and therapeutic efficacy, although studies have shown that overall/total...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33755138
DOI: 10.1093/jnen/nlab008

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