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Article

DNA copy number patterns reveal prognostic markers and elucidate mechanisms of evolution in IDH-mutant astrocytoma.

Neuro-oncology - 1 Jun 2026

Drucker Kristen L, Panda Arijit, Decker Paul A, Kosel Matt L, Kollmeyer Thomas M, Burns Terry C, Maqbool Muhammad Asad, Shafqat Shameel, Suvakov Milovan, Zadeh Gelareh, Giannini Caterina, Vaubel Rachael, Raghunathan Aditya, Parney Ian F, Kizilbash Sani H, Ida Cristiane M, Abyzov Alexej, Lachance Daniel H, Eckel-Passow Jeanette E, Jenkins Robert B

Abstract excerpt

BACKGROUND: Current literature suggestsisocitrate dehydrogenase (IDH)-mutant astrocytoma contains several molecular subgroups. In this study, we are interested in determining the connection between different molecular subgroups with grade and/or survival. METHODS: A cohort of 470 Mayo Clinic adult patients (≥18 years, 56.2% male) with primary IDH-mutant astrocytoma diagnosed by World Health Organization (WHO)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41761580
DOI: 10.1093/neuonc/noag019
PMCID: PMC13051352

Genes

CDKN2A
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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