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Article

Total copy number variation as a prognostic factor in adult astrocytoma subtypes

9 Jun 2019

Abstract excerpt

Since the discovery that IDH1/2 mutations confer a significantly better prognosis in astrocytomas, much work has been done to identify other molecular signatures to help further stratify lower-grade astrocytomas and glioblastomas, with the goal of accurately predicting clinical outcome and identifying potentially targetable mutations. In the present study, we subclassify 135 astrocytomas (67 IDH-wildtype and 68...

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PMID: 31177992
DOI: 10.1186/s40478-019-0746-y

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