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Article

Assessment of the Type and Degree of Genomic Instability in Gliomas.

International journal of molecular sciences - 15 Mar 2026

Ademović Nejla, Milić Marina, Tomić Tijana, Murganić Blagoje, Milić Ivan, Tanić Nasta, Tanić Nikola

Abstract excerpt

Glial brain tumours, including astrocytoma IDH (Isocitrate Dehydrogenase) mutant and glioblastoma IDH wild-type, are highly malignant brain tumours with poor clinical outcomes. Genomic instability, encompassing microsatellite (MIN) and chromosomal instability (CIN), drives tumour heterogeneity and evolution. In this study, genomic instability was analysed in 85 patients using AP-PCR (Arbitrarily Primed Polymerase...

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Identifiers

PMID: 41898543
DOI: 10.3390/ijms27062678
PMCID: PMC13026593

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