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GREB1 is an estrogen receptor-regulated tumour promoter that is frequently expressed in ovarian cancer

4 Jul 2018

Abstract excerpt

Estrogenic hormone replacement therapy increases the risk of developing ovarian cancer, and estrogen promotes tumour initiation and growth in mouse models of this disease. GREB1 (Growth regulation by estrogen in breast cancer 1) is an ESR1 (estrogen receptor 1)-upregulated protein which may mediate estrogen action. GREB1 knockdown prevents hormone-driven proliferation of several breast and prostate cancer cell...

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Share to Endometrial and Cervical Cancer Treatments
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PMID: 29973689
DOI: 10.1038/s41388-018-0377-y

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