Article

Estrogen-related receptor alpha (ERRα) promotes gastrointestinal stromal tumor progression and epithelial-mesenchymal transition through Wnt/β-catenin

2026-06-24

Abstract excerpt

<title>Abstract</title> <p> Gastrointestinal stromal tumor (GIST) is the most common human sarcoma and primarily driven by a gain-of-function mutation in either the KIT or PDGFRA receptor tyrosine kinase. Estrogen-related receptor alpha (ERRα, encoded by <italic>ESRRA</italic> ) is an orphan nuclear receptor that shares structural homology and overlapping transcriptional targets with estrogen receptor alpha (E...

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Literature Corpus work: 369e7aaf-ce8a-571e-aee7-7e2056be1379
DOI: 10.21203/rs.3.rs-9930164/v1

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