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Endogenous Purification Reveals GREB1 as a Key Estrogen Receptor Regulatory Factor

1 Feb 2013

Abstract excerpt

Estrogen receptor-α (ER) is the driving transcription factor in most breast cancers, and its associated proteins can influence drug response, but direct methods for identifying interacting proteins have been limited. We purified endogenous ER using an approach termed RIME (rapid immunoprecipitation mass spectrometry of endogenous proteins) and discovered the interactome under agonist- and antagonist-liganded...

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PMID: 23403292
DOI: 10.1016/j.celrep.2013.01.010

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