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Article

Limited Predictability of Amino Acid Substitutions in Seasonal Influenza Viruses

3 Mar 2021

Abstract excerpt

Seasonal influenza viruses repeatedly infect humans in part because they rapidly change their antigenic properties and evade host immune responses, necessitating frequent updates of the vaccine composition. Accurate predictions of strains circulating in the future could therefore improve the vaccine match. Here, we studied the predictability of frequency dynamics and fixation of amino acid substitutions. Current...

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PMID: 33749787
DOI: 10.1093/molbev/msab065

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