Article
Natural selection for nucleotide usage at synonymous and nonsynonymous sites in influenza A virus genes.
Journal of virology - 1 May 2008
Kryazhimskiy Sergey, Bazykin Georgii A, Dushoff Jonathan
Abstract excerpt
Influenza A virus is one of the best-studied viruses and a model organism for the study of molecular evolution; in particular, much research has focused on detecting natural selection on influenza virus proteins. Here, we study the dynamics of the synonymous and nonsynonymous nucleotide composition of influenza A virus genes. In several genes, the nucleotide frequencies at synonymous positions drift away from the...
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