Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Incorporating European GWAS findings improve polygenic risk prediction accuracy of breast cancer among East Asians.

Genetic epidemiology - 1 Jul 2021

Ji Ying, Long Jirong, Kweon Sun-Seog, Kang Daehee, Kubo Michiaki, Park Boyoung, Shu Xiao-Ou, Zheng Wei, Tao Ran, Li Bingshan

Abstract excerpt

Previous genome-wide association studies (GWASs) have been largely focused on European (EUR) populations. However, polygenic risk scores (PRSs) derived from EUR have been shown to perform worse in non-EURs compared with EURs. In this study, we aim to improve PRS prediction in East Asians (EASs). We introduce a rescaled meta-analysis framework to combine both EUR (N = 122,175) and EAS (N = 30,801) GWAS summary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Multifactorial Inheritance

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 33739539
DOI: 10.1002/gepi.22382
PMCID: PMC8372543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Incorporating European GWAS findings improve polygenic risk prediction accuracy of breast cancer among East Asians.PMID 33739539Read ↗

Polygenic Risk Scores for Prediction of Breast Cancer in Korean womenSemantic proximity Read ↗

Polygenic risk scores for prediction of breast cancer in Korean women.Semantic proximity Read ↗

Predictive performance of breast cancer polygenic risk scores from diverse ancestries: a prospective study in Japanese women.Semantic proximity Read ↗

European polygenic risk score for prediction of breast cancer shows similar performance in Asian women.Semantic proximity Read ↗

Development of a Breast Cancer Risk Prediction Model Incorporating Polygenic Risk Scores and Nongenetic Risk Factors for Korean Women.Semantic proximity Read ↗

Assessment of polygenic risk score performance in East Asian populations for ten common diseasesSemantic proximity Read ↗

On Cross-ancestry Cancer Polygenic Risk ScoresSemantic proximity Read ↗

Risk assessment for colorectal cancer via polygenic risk score and lifestyle exposure: a large-scale association study of East Asian and European populations.Semantic proximity Read ↗

On cross-ancestry cancer polygenic risk scores.Semantic proximity Read ↗

Assessment of polygenic risk score performance in East Asian populations for ten common diseases: A Korean cohort studySemantic proximity Read ↗

Development and validation of genome-wide polygenic risk scores for predicting breast cancer incidence in Japanese females: a population-based case-cohort study.Semantic proximity Read ↗

Evaluation of European-based polygenic risk score for breast cancer in Ashkenazi Jewish women in Israel.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.