Lifespan extension conferred by mitogen-activated protein kinase kinase kinase 5 (MAP3K5) longevity-associated gene variation is confined to at-risk men with a cardiometabolic disease.

doi:10.18632/aging.202844

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Lifespan extension conferred by mitogen-activated protein kinase kinase kinase 5 (MAP3K5) longevity-associated gene variation is confined to at-risk men with a cardiometabolic disease.

Aging - 19 Mar 2021

Morris Brian J, Chen Randi, Donlon Timothy A, Masaki Kamal H, Willcox D Craig, Allsopp Richard C, Willcox Bradley J

Abstract excerpt

Genetic variants of the kinase signaling gene MAP3K5 are associated with longevity. Here we explore whether the longevity-association involves protection against mortality in all individuals, or only in individuals with aging-related diseases. We tested the strongest longevity associated single nucleotide polymorphism (SNP), rs2076260, for association with mortality in 3,516 elderly American men of Japanese...

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PMID: 33739303
DOI: 10.18632/aging.202844
PMCID: PMC8034933

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