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Article

Association of growth hormone receptor gene variant with longevity in men is due to amelioration of increased mortality risk from hypertension.

Aging - 1 Jun 2021

Donlon Timothy A, Chen Randi, Masaki Kamal H, Willcox D Craig, Allsopp Richard C, Willcox Bradley J, Morris Brian J

Abstract excerpt

The single nucleotide polymorphism (SNP) rs4130113 of the growth hormone receptor gene (GHR) is associated with longevity. Here we explored whether longevity-associated genotypes protect against mortality in all individuals, or only in individuals with aging-related diseases. Rs4130113 genotypes were tested for association with mortality in 3,557 elderly American men of Japanese ancestry. At baseline (1991-1993),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34074802
DOI: 10.18632/aging.203133
PMCID: PMC8221335

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