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Article

Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity.

The journals of gerontology. Series A, Biological sciences and medical sciences - 8 Oct 2018

Donlon Timothy A, Morris Brian J, Chen Randi, Masaki Kamal H, Allsopp Richard C, Willcox D Craig, Tiirikainen Maarit, Willcox Bradley J

Abstract excerpt

Longevity is a polygenic trait in which genetic predisposition is particularly important. We hypothesized that among genes differentially expressed in response to caloric restriction, several may be candidate longevity genes. We tested 459 single-nucleotide polymorphisms (SNPs) in 47 genes differentially expressed in calorically restricted mice and 12 other genes for association with longevity. Subjects were...

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Identifiers

PMID: 29300832
DOI: 10.1093/gerona/glx247
PMCID: PMC6175033

Genes

MAP3K5
FLT1
SIRT5
SIRT7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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