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The first two blastomeres contribute unequally to the human embryo

1 May 2024

Abstract excerpt

Retrospective lineage reconstruction of humans predicts that dramatic clonal imbalances in the body can be traced to the 2-cell stage embryo. However, whether and how such clonal asymmetries arise in the embryo is unclear. Here, we performed prospective lineage tracing of human embryos using live imaging, non-invasive cell labeling, and computational predictions to determine the contribution of each 2-cell stage...

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Identifiers

PMID: 38744282
DOI: 10.1016/j.cell.2024.04.029

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