Article
Analysis of family- and population-based samples in cohort genome-wide association studies.
Human genetics - 1 Feb 2012
Manichaikul Ani, Chen Wei-Min, Williams Kayleen, Wong Quenna, Sale Michèle M, Pankow James S, Tsai Michael Y, Rotter Jerome I, Rich Stephen S, Mychaleckyj Josyf C
Abstract excerpt
Cohort studies typically sample unrelated individuals from a population, although family members of index cases may also be recruited to investigate shared familial risk factors. Recruitment of family members may be incomplete or ancillary to the main cohort, resulting in a mixed sample of independent family units, including unrelated singletons and multiplex families. Multiple methods are available to perform...
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