Article
The Emerging Role of Ras Pathway Signaling in Pediatric Cancer.
Cancer research - 1 Dec 2020
Ney Gina M, McKay Laura, Koschmann Carl, Mody Rajen, Li Qing
Abstract excerpt
As genomic sequencing has become more widely available, the high prevalence of Ras pathway mutations in pediatric diseases has begun to emerge. Germline Ras-activating mutations have been known to contribute to cancer predisposition in a group of disorders known as the RASopathies, and now large pediatric sequencing studies have identified frequent somatic Ras pathway alterations across a diverse group of...
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