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Article

A heterochromatin inducing protein differentially recognizes self versus foreign genomes

17 Mar 2021

Abstract excerpt

Krüppel-associated box-domain zinc finger protein (KRAB-ZFP) transcriptional repressors recruit TRIM28/KAP1 to heterochromatinize the mammalian genome while also guarding the host by silencing invading foreign genomes. However, how a KRAB-ZFP recognizes target sequences in the natural context of its own or foreign genomes is unclear. Our studies on B-lymphocytes permanently harboring the cancer-causing...

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PMID: 33730092
DOI: 10.1371/journal.ppat.1009447

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