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Article

Novel functional variants in the Notch pathway and survival of Chinese colorectal cancer.

International journal of cancer - 1 Jul 2021

Qu Xiaofei, Zhao Liqin, Wang Mengyun, Zhang Ruoxin, Cheng Lei, Qiu Lixin, Tong Xiaoxia, Cai Sanjun, Wei Qingyi, Li Qingguo

Abstract excerpt

Notch signaling pathway plays crucial roles in progression of colorectal cancer (CRC), likely affecting overall survival (OS). In a two-stage survival analysis of 1116 CRC patients in East China, we found that one locus at MINAR1 out of 133 genes in the Notch signaling pathway was significantly associated with OS (P < 1 × 10-6 , false discovery rate < 0.01). This locus containing seven single-nucleotide...

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PMID: 33728681
DOI: 10.1002/ijc.33561

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