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Article

Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

Nature genetics - 1 Jun 2014

Zhang Ben, Jia Wei-Hua, Matsuda Koichi, Kweon Sun-Seog, Matsuo Keitaro, Xiang Yong-Bing, Shin Aesun, Jee Sun Ha, Kim Dong-Hyun, Cai Qiuyin, Long Jirong, Shi Jiajun, Wen Wanqing, Yang Gong, Zhang Yanfeng, Li Chun, Li Bingshan, Guo Yan, Ren Zefang, Ji Bu-Tian, Pan Zhi-Zhong, Takahashi Atsushi, Shin Min-Ho, Matsuda Fumihiko, Gao Yu-Tang, Oh Jae Hwan, Kim Soriul, Ahn Yoon-Ok, Chan Andrew T, Chang-Claude Jenny, Slattery Martha L, Gruber Stephen B, Schumacher Fredrick R, Stenzel Stephanie L, Casey Graham, Kim Hyeong-Rok, Jeong Jin-Young, Park Ji Won, Li Hong-Lan, Hosono Satoyo, Cho Sang-Hee, Kubo Michiaki, Shu Xiao-Ou, Zeng Yi-Xin, Zheng Wei

Abstract excerpt

Known genetic loci explain only a small proportion of the familial relative risk of colorectal cancer (CRC). We conducted a genome-wide association study of CRC in East Asians with 14,963 cases and 31,945 controls and identified 6 new loci associated with CRC risk (P = 3.42 × 10(-8) to 9.22 × 10(-21)) at 10q22.3, 10q25.2, 11q12.2, 12p13.31, 17p13.3 and 19q13.2. Two of these loci map to genes (TCF7L2 and TGFB1)...

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Source

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Identifiers

PMID: 24836286
DOI: 10.1038/ng.2985
PMCID: PMC4068797

Genes

CD9
FADS1
FADS2
FEN1
NXN
TCF7L2
TGFB1
ZMIZ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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