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Article

Potential regulatory SNPs in the ATXN7L3B and KRT15 genes are associated with gender-specific colorectal cancer risk.

Personalized medicine - 1 Jan 2020

Leberfarb Elena Yu, Degtyareva Arina O, Brusentsov Ilya I, Maximov Vladimir N, Voevoda Mikhail I, Autenshlus Alexander I, Morozov Dmitriy V, Sokolov Andrey V, Merkulova Tatiana I

Abstract excerpt

Aim: According to the current data, a major factor for phenotypic variation of complex traits and disease susceptibility is the cis-acting effects of noncoding variants on gene expression. Our purpose was to evaluate the association between colorectal cancer (CRC) and six single nucleotide polymorphisms identified using our original bioinformatics approach as regulatory and putatively related to CRC. Materials:...

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PMID: 31797724
DOI: 10.2217/pme-2019-0059

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