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Article

SNPs associated with colorectal cancer at 15q13.3 affect risk enhancers that modulate GREM1 gene expression.

Human mutation - 1 Mar 2021

Fortini Barbara K, Tring Stephanie, Devall Matthew A, Ali Mourad Wagdy, Plummer Sarah J, Casey Graham

Abstract excerpt

Several genome wide association studies of colorectal cancer (CRC) have identified single nucleotide polymorphisms (SNPs) on chromosome 15q13.3 associated with CRC risk. To identify functional variant(s) underlying this association, we investigated SNPs in linkage disequilibrium with the risk-associated SNP rs4779584 that overlapped regulatory regions/enhancer elements characterized in colon-related tissues and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33476087
DOI: 10.1002/humu.24166
PMCID: PMC7898835

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