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Article

Single nucleotide polymorphisms within interferon signaling pathway genes are associated with colorectal cancer susceptibility and survival.

PloS one - 1 Jan 2014

Lu Shun, Pardini Barbara, Cheng Bowang, Naccarati Alessio, Huhn Stefanie, Vymetalkova Veronika, Vodickova Ludmila, Buchler Thomas, Hemminki Kari, Vodicka Pavel, Försti Asta

Abstract excerpt

Interferon (IFN) signaling has been suggested to play an important role in colorectal carcinogenesis. Our study aimed to examine potentially functional genetic variants in interferon regulatory factor 3 (IRF3), IRF5, IRF7, type I and type II IFN and their receptor genes with respect to colorectal cancer (CRC) risk and clinical outcome. Altogether 74 single nucleotide polymorphisms (SNPs) were covered by the 34...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25350395
DOI: 10.1371/journal.pone.0111061
PMCID: PMC4211713

Genes

IFNAR1
IFNGR1
IFNA1
IFNA13
IFNA14
IFNA21
IFNA7
IFNK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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