Article
Genetic variant of MAML2 in the NOTCH signaling pathway and the risk of bladder cancer: A STROBE-compliant study.
Medicine - 1 Jan 2020
Shen Yang, Lu Qian, Ye Hesong, Deng Zhonglei, Ma Long, Zhang Qingling, Tang Jingyuan, Yuan Lin
Abstract excerpt
The NOTCH signaling pathway plays a crucial role in cell phenotype and transformation. Single nucleotide polymorphisms (SNPs) may regulate gene expression to trigger bladder cancer susceptibility. Here, we aimed to explore the relationships between genetic variants in the NOTCH pathway and bladder cancer progression.We screened SNPs located in NOTCH pathway genes using the 1000 Genomes Project dataset (CHB). A...
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