Article
Variants in Notch signalling pathway genes, PSEN1 and MAML2, predict overall survival in Chinese patients with epithelial ovarian cancer.
Journal of cellular and molecular medicine - 1 Oct 2018
Xu Yuan, Cheng Lei, Dai Hongji, Zhang Ruoxin, Wang Mengyun, Shi Tingyan, Sun Menghong, Cheng Xi, Wei Qingyi
Abstract excerpt
To identify genetic variants in Notch signalling pathway genes that may predict survival of Han Chinese patients with epithelial ovarian cancer (EOC), we analysed a total of 1273 single nucleotide polymorphisms (SNPs) within 75 Notch genes in 480 patients from a published EOC genomewide association study (GWAS). We found that PSEN1 rs165934 and MAML2 rs76032516 were associated with overall survival (OS) of...
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