Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction.

doi:10.1038/s41467-021-21931-9

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Article

Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction.

Nature communications - 16 Mar 2021

Schiattarella Gabriele G, Altamirano Francisco, Kim Soo Young, Tong Dan, Ferdous Anwarul, Piristine Hande, Dasgupta Subhajit, Wang Xuliang, French Kristin M, Villalobos Elisa, Spurgin Stephen B, Waldman Maayan, Jiang Nan, May Herman I, Hill Theodore M, Luo Yuxuan, Yoo Heesoo, Zaha Vlad G, Lavandero Sergio, Gillette Thomas G, Hill Joseph A

Abstract excerpt

Heart failure with preserved ejection fraction (HFpEF) is now the dominant form of heart failure and one for which no efficacious therapies exist. Obesity and lipid mishandling greatly contribute to HFpEF. However, molecular mechanism(s) governing metabolic alterations and perturbations in lipid homeostasis in HFpEF are largely unknown. Here, we report that cardiomyocyte steatosis in HFpEF is coupled with...

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Identifiers

PMID: 33727534
DOI: 10.1038/s41467-021-21931-9
PMCID: PMC7966396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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