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Cardiac proteostasis in obesity and cardiovascular disease

8 Feb 2024

Abstract excerpt

Cardiovascular diseases (CVD) are closely linked to protein homeostasis (proteostasis) and its failure. Beside genetic mutations that impair cardiac protein quality control, obesity is a strong risk factor for heart disease. In obesity, adipose tissue becomes dysfunctional and impacts heart function and CVD progression by releasing cytokines that contribute to systemic insulin resistance and cardiovascular...

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PMID: 38329532
DOI: 10.1007/s00059-024-05233-6

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