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Article

The multifaceted impact of physical exercise on FoxO signaling pathways

8 Aug 2025

Abstract excerpt

This review explores the multifaceted impact of physical exercise on FoxO signaling pathways, which play a central role in cellular homeostasis, stress response, metabolism, and longevity. Exercise influences FoxO proteins-particularly FoxO1, FoxO3, FoxO4, and FoxO6-through diverse mechanisms, including phosphorylation, acetylation, and ubiquitination, determining their localization, transcriptional activity, and...

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PMID: 40861274
DOI: 10.3389/fcell.2025.1614732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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