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Article

Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction.

Nature medicine - 1 Mar 2011

Zhou Yingjiang, Lee Justin, Reno Candace M, Sun Cheng, Park Sang Won, Chung Jason, Lee Jaemin, Fisher Simon J, White Morris F, Biddinger Sudha B, Ozcan Umut

Abstract excerpt

To date, the only known role of the spliced form of X-box-binding protein-1 (XBP-1s) in metabolic processes has been its ability to act as a transcription factor that regulates the expression of genes that increase the endoplasmic reticulum (ER) folding capacity, thereby improving insulin sensitivity. Here we show that XBP-1s interacts with the Forkhead box O1 (FoxO1) transcription factor and directs it toward...

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Source

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Identifiers

PMID: 21317886
DOI: 10.1038/nm.2293
PMCID: PMC3897616

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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