Article

Loss of MGST1 during fibroblast differentiation enhances vulnerability to oxidative stress in human heart failure

2025-11-15

Abstract excerpt

<h4>Background</h4> Oxidative stress (OS) resulting from an imbalance between reactive oxygen species (ROS) production and antioxidant defences is a major mechanism exacerbating HF, involving activation of cardiac fibroblasts (FB) and fibrosis. In addition to reducing ROS production and/or scavenging, boosting cellular anti-oxidant capacity is a potential strategy, with FB an interesting target. <h4>Methods</h4>...

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Literature Corpus work: 9346f49c-2a8b-5652-bc29-86f339c2666d
DOI: 10.1101/2025.11.14.688417

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