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Article

TGFβ receptor mutations impose a strong predisposition for human allergic disease.

Science translational medicine - 24 Jul 2013

Frischmeyer-Guerrerio Pamela A, Guerrerio Anthony L, Oswald Gretchen, Chichester Kristin, Myers Loretha, Halushka Marc K, Oliva-Hemker Maria, Wood Robert A, Dietz Harry C

Abstract excerpt

Transforming growth factor-β (TGFβ) is a multifunctional cytokine that plays diverse roles in physiologic processes as well as human disease, including cancer, heart disease, and fibrotic disorders. In the immune system, TGFβ regulates regulatory T cell (Treg) maturation and immune homeostasis. Although genetic manipulation of the TGFβ pathway modulates immune tolerance in mouse models, the contribution of this...

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Source

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Identifiers

PMID: 23884466
DOI: 10.1126/scitranslmed.3006448
PMCID: PMC3905327

Genes

TGFBR1
TGFBR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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