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Article

Id3 is a novel atheroprotective factor containing a functionally significant single-nucleotide polymorphism associated with intima-media thickness in humans.

Circulation research - 16 Apr 2010

Doran Amanda C, Lehtinen Allison B, Meller Nahum, Lipinski Michael J, Slayton R Parker, Oldham Stephanie N, Skaflen Marcus D, Yeboah Joseph, Rich Stephen S, Bowden Donald W, McNamara Coleen A

Abstract excerpt

RATIONALE: The gene encoding the helix-loop-helix transcription factor Id3 (inhibitor of differentiation-3) is located within atherosclerosis susceptibility loci of both mice and humans, yet its influence on atherosclerosis is not known. OBJECTIVE: The present study sought to determine whether polymorphisms in the ID3 gene were associated with indices of atherosclerosis in humans and if loss of Id3 function...

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Identifiers

PMID: 20185798
DOI: 10.1161/CIRCRESAHA.109.210294
PMCID: PMC2860382

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