Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A possible role for proinflammatory activation via cGAS-STING pathway in atherosclerosis induced by accumulation of DNA double-strand breaks

30 Sept 2023

Abstract excerpt

Abstract DNA damage contributes to atherosclerosis. However, causative links between DNA double-strand breaks (DSBs) and atherosclerosis have yet to be established. Here, we investigated the role of DSBs in atherosclerosis using mice and vascular cells deficient in Ku80, a DSB repair protein. After 4 weeks of a high-fat diet, Ku80-deficient apolipoprotein E knockout mice (Ku80+/−ApoE−/−) displayed increased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Inflammasome and immune disorders
Share to interferon and immune responses
Share to Mosquito-borne diseases and control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37777633
DOI: 10.1038/s41598-023-43848-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A possible role for proinflammatory activation via cGAS-STING pathway in atherosclerosis induced by accumulation of DNA double-strand breaksPMID 37777633Read ↗

Significance of the cGAS-STING Pathway in Health and DiseaseSemantic proximity Read ↗

Dietary Restriction Mitigates Vascular Aging, Modulates the cGAS-STING Pathway and Reverses Macrophage-Like VSMC Phenotypes in Progeroid DNA-Repair-Deficient Ercc1Δ /- Mice.Semantic proximity Read ↗

DNA Damage and Senescence-Associated Inflammation in Cardiovascular DiseaseSemantic proximity Read ↗

The cGAS/STING signaling pathway: a cross-talk of infection, senescence and tumorsSemantic proximity Read ↗

DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development.Semantic proximity Read ↗

Alteration of cGAS-STING signaling pathway components in the mouse cortex and hippocampus during healthy brain agingSemantic proximity Read ↗

The cGAS/STING pathway: a sensor of senescence-associated DNA damage and trigger of inflammation in early age-related macular degenerationSemantic proximity Read ↗

Reduction of double-strand DNA break repair exacerbates vascular agingSemantic proximity Read ↗

DNA damage response, a double-edged sword for vascular agingSemantic proximity Read ↗

Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injurySemantic proximity Read ↗

DNA Damage and Repair in Atherosclerosis: Current Insights and Future PerspectivesSemantic proximity Read ↗

The role of the cGAS-STING pathway in metabolic diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.