Article
NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype.
Scientific reports - 5 Oct 2021
Karlsen Tom Rune, Kong Xiang Yi, Holm Sverre, Quiles-Jiménez Ana, Dahl Tuva B, Yang Kuan, Sagen Ellen L, Skarpengland Tonje, S Øgaard Jonas D, Holm Kristian, Vestad Beate, Olsen Maria B, Aukrust Pål, Bjørås Magnar, Hov Johannes R, Halvorsen Bente, Gregersen Ida
Abstract excerpt
Atherosclerosis and its consequences cause considerable morbidity and mortality world-wide. We have previously shown that expression of the DNA glycosylase NEIL3 is regulated in human atherosclerotic plaques, and that NEIL3-deficiency enhances atherogenesis in Apoe-/- mice. Herein, we identified a time point prior to quantifiable differences in atherosclerosis between Apoe-/-Neil3-/- mice and Apoe-/- mice. Mice...
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