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Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

24 Sept 2013

Abstract excerpt

BACKGROUND: Although aberrant DNA methylation has been observed previously in acute lymphoblastic leukemia (ALL), the patterns of differential methylation have not been comprehensively determined in all subtypes of ALL on a genome-wide scale. The relationship between DNA methylation, cytogenetic background, drug resistance and relapse in ALL is poorly understood. RESULTS: We surveyed the DNA methylation levels of...

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PMID: 24063430
DOI: 10.1186/gb-2013-14-9-r105

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