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Article

Beyond ATRX: The heterogeneous basis of Alternative Lengthening of Telomeres in osteosarcoma.

Cancer genetics - 1 Sept 2026

Goncalves Tomas, Mattis Natalie S, Mitchell Amy F M, Rose Anna M

Abstract excerpt

The alternative lengthening of telomeres (ALT) pathway is a telomerase-independent telomere maintenance mechanism, which is frequently observed in osteosarcoma. In this study, we performed a systematic review of studies assessing ALT in patient-derived osteosarcoma samples using direct experimental assays, alongside bioinformatic analysis of large public genomic datasets to evaluate the prevalence of canonical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42330800
DOI: 10.1016/j.cancergen.2026.06.001

Genes

ATRX
DAXX
TOP3A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Beyond ATRX: The heterogeneous basis of Alternative Lengthening of Telomeres in osteosarcoma.PMID 42330800Read ↗

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Alternative lengthening of telomeres: mechanism and the pathogenesis of cancerSemantic proximity Read ↗

Pan-Cancer Analysis of Alternative Lengthening of Telomere ActivitySemantic proximity Read ↗

TCGA Pan-Cancer Genomic Analysis of Alternative Lengthening of Telomeres (ALT) Related Genes.Semantic proximity Read ↗

ALT Positivity in Human Cancers: Prevalence and Clinical InsightsSemantic proximity Read ↗

Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooksSemantic proximity Read ↗

The ALT pathway generates telomere fusions that can be detected in the blood of cancer patientsSemantic proximity Read ↗

Genomic Landscape of Osteosarcoma of Bone in an Older-Aged Patient Population and Analysis of Possible Etiologies Based on Molecular Signature.Semantic proximity Read ↗

Alternative Lengthening of Telomeres: Building Bridges To Connect Chromosome Ends.Semantic proximity Read ↗

Telomere sequence content can be used to determine ALT activity in tumours.Semantic proximity Read ↗

Multi-omics analysis identifies osteosarcoma subtypes with distinct prognosis indicating stratified treatmentSemantic proximity Read ↗

Alternative lengthening of telomeres is not synonymous with mutations in ATRX/DAXXSemantic proximity Read ↗

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