Article
ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells.
Haematologica - 1 Mar 2022
Madan Vikas, Cao Zeya, Teoh Weoi Woon, Dakle Pushkar, Han Lin, Shyamsunder Pavithra, Jeitany Maya, Zhou Siqin, Li Jia, Nordin Hazimah Binte Mohd, Shi JiZhong, Yu Shuizhou, Yang Henry, Hossain Md Zakir, Chng Wee Joo, Koeffler H Phillip
Abstract excerpt
Recurrent loss-of-function mutations of spliceosome gene, ZRSR2, occur in myelodysplastic syndromes (MDS). Mutation/loss of ZRSR2 in human myeloid cells primarily causes impaired splicing of the U12-type introns. In order to further investigate the role of this splice factor in RNA splicing and hematopoietic development, we generated mice lacking ZRSR2. Unexpectedly, Zrsr2-deficient mice developed normal...
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