Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RUNX1 deficiency cooperates with SRSF2 mutation to induce multilineage hematopoietic defects characteristic of MDS.

Blood advances - 13 Dec 2022

Huang Yi-Jou, Chen Jia-Yu, Yan Ming, Davis Amanda G, Miyauchi Sayuri, Chen Liang, Hao Yajing, Katz Sigrid, Bejar Rafael, Abdel-Wahab Omar, Fu Xiang-Dong, Zhang Dong-Er

Abstract excerpt

Myelodysplastic syndromes (MDSs) are a heterogeneous group of hematologic malignancies with a propensity to progress to acute myeloid leukemia. Causal mutations in multiple classes of genes have been identified in patients with MDS with some patients harboring more than 1 mutation. Interestingly, double mutations tend to occur in different classes rather than the same class of genes, as exemplified by frequent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Core Binding Factor Alpha 2 Subunit
Share to Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Myelodysplastic Syndromes

Share to RNA Splicing

Share to Serine-Arginine Splicing Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 36206200
DOI: 10.1182/bloodadvances.2022007804
PMCID: PMC9772487

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RUNX1 deficiency cooperates with SRSF2 mutation to induce multilineage hematopoietic defects characteristic of MDS.PMID 36206200Read ↗

Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic neoplasm in mice.Semantic proximity Read ↗

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.Semantic proximity Read ↗

Distinct and convergent consequences of splice factor mutations in myelodysplastic syndromes.Semantic proximity Read ↗

SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition.Semantic proximity Read ↗

<i> Srsf2 <sup>P95H/+</sup> </i> co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia like disease in miceSemantic proximity Read ↗

SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing.Semantic proximity Read ↗

SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells.Semantic proximity Read ↗

Srsf2P95H/+ co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia-like disease in mice.Semantic proximity Read ↗

Impaired hematopoiesis and leukemia development in mice with a conditional “knock-in” allele of a mutant splicing factor gene <i>U2af1</i>Semantic proximity Read ↗

The functional mechanisms of mutations in myelodysplastic syndrome.Semantic proximity Read ↗

Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1Semantic proximity Read ↗

Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.