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Article

Dysregulated minor intron splicing in cancer.

Cancer science - 1 Sept 2022

Nishimura Koutarou, Yamazaki Hiromi, Zang Weijia, Inoue Daichi

Abstract excerpt

Pre-mRNA splicing is now widely recognized as a cotranscriptional and post-transcriptional mechanism essential for regulating gene expression and modifying gene product function. Mutations in genes encoding core spliceosomal proteins and accessory regulatory splicing factors are now considered among the most recurrent genetic abnormalities in patients with cancer, particularly hematologic malignancies. These...

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PMID: 35766428
DOI: 10.1111/cas.15476
PMCID: PMC9459249

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