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Article

Opposite Effects of M1 and M2 Macrophage Subtypes on Lung Cancer Progression.

Scientific reports - 24 Sept 2015

Yuan Ang, Hsiao Yi-Jing, Chen Hsuan-Yu, Chen Huei-Wen, Ho Chao-Chi, Chen Yu-Yun, Liu Yi-Chia, Hong Tsai-Hsia, Yu Sung-Liang, Chen Jeremy J W, Yang Pan-Chyr

Abstract excerpt

Macrophages in a tumor microenvironment have been characterized as M1- and M2-polarized subtypes. Here, we discovered the different macrophages' impacts on lung cancer cell A549. The M2a/M2c subtypes promoted A549 invasion and xenograft tumor growth. The M1 subtype suppressed angiogenesis. M1 enhanced the sensitivity of A549 to cisplatin and decreased the tube formation activity and cell viability of A549 cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26399191
DOI: 10.1038/srep14273
PMCID: PMC4585843

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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