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Article

A Time- and Compartment-Specific Activation of Lung Macrophages in Hypoxic Pulmonary Hypertension.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2017

Pugliese Steven C, Kumar Sushil, Janssen William J, Graham Brian B, Frid Maria G, Riddle Suzette R, El Kasmi Karim C, Stenmark Kurt R

Abstract excerpt

Studies in various animal models suggest an important role for pulmonary macrophages in the pathogenesis of pulmonary hypertension (PH). Yet, the molecular mechanisms characterizing the functional macrophage phenotype relative to time and pulmonary localization and compartmentalization remain largely unknown. In this study, we used a hypoxic murine model of PH in combination with FACS to quantify and isolate lung...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28500078
DOI: 10.4049/jimmunol.1601692
PMCID: PMC5501258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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