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HLA variants and TCR diversity against SARS-CoV-2 in the pre-COVID-19 era.

HLA - 1 Dec 2023

Buhler Stéphane, Sollet Zuleika Calderin, Bettens Florence, Schäfer Antonia, Ansari Marc, Ferrari-Lacraz Sylvie, Villard Jean

Abstract excerpt

HLA antigen presentation and T-cell mediated immunity are critical to control acute viral infection such as COVID-19 caused by SARS-CoV-2. Recent data suggest that both the depth of peptide presentation and the breadth of the T-cell repertoire are associated with disease outcome. It has also been shown that unexposed subjects can develop strong T-cell responses against SARS-CoV-2 due to heterologous immunity. In...

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PMID: 37461808
DOI: 10.1111/tan.15158

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