Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features.

doi:10.1038/s41467-021-22811-y

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Article

Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features.

Nature communications - 10 May 2021

Gangaev Anastasia, Ketelaars Steven L C, Isaeva Olga I, Patiwael Sanne, Dopler Anna, Hoefakker Kelly, De Biasi Sara, Gibellini Lara, Mussini Cristina, Guaraldi Giovanni, Girardis Massimo, Ormeno Cami M P Talavera, Hekking Paul J M, Lardy Neubury M, Toebes Mireille, Balderas Robert, Schumacher Ton N, Ovaa Huib, Cossarizza Andrea, Kvistborg Pia

Abstract excerpt

The COVID-19 pandemic caused by SARS-CoV-2 is a continuous challenge worldwide, and there is an urgent need to map the landscape of immunogenic and immunodominant epitopes recognized by CD8+ T cells. Here, we analyze samples from 31 patients with COVID-19 for CD8+ T cell recognition of 500 peptide-HLA class I complexes, restricted by 10 common HLA alleles. We identify 18 CD8+ T cell recognized SARS-CoV-2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33972535
DOI: 10.1038/s41467-021-22811-y
PMCID: PMC8110804

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