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Article

The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA-supertype-dependent manner.

Cell systems - 16 Feb 2022

Hamelin David J, Fournelle Dominique, Grenier Jean-Christophe, Schockaert Jana, Kovalchik Kevin A, Kubiniok Peter, Mostefai Fatima, Duquette Jérôme D, Saab Frederic, Sirois Isabelle, Smith Martin A, Pattijn Sofie, Soudeyns Hugo, Decaluwe Hélène, Hussin Julie, Caron Etienne

Abstract excerpt

The rapid, global dispersion of SARS-CoV-2 has led to the emergence of a diverse range of variants. Here, we describe how the mutational landscape of SARS-CoV-2 has shaped HLA-restricted T cell immunity at the population level during the first year of the pandemic. We analyzed a total of 330,246 high-quality SARS-CoV-2 genome assemblies, sampled across 143 countries and all major continents from December 2019 to...

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Identifiers

PMID: 34637888
DOI: 10.1016/j.cels.2021.09.013
PMCID: PMC8492600

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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