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Article

Phosphatase PP2A enhances MCL-1 protein half-life in multiple myeloma cells

3 Mar 2021

Abstract excerpt

Multiple myeloma (MM), a treatable but incurable malignancy, is characterized by the growth of clonal plasma cells in protective niches in the bone marrow. MM cells depend on expression of BCL-2 family proteins, in particular MCL-1, for survival. The regulation of MCL-1 is complex and cell type-dependent. Unraveling the exact mechanism by which MCL-1 is overexpressed in MM may provide new therapeutic strategies...

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PMID: 33658484
DOI: 10.1038/s41419-020-03351-7

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