Article

Lysin (K)-Specific Demethylase 1 Inhibition Enhances Proteasome Inhibitor Response and Overcomes Drug Resistance in Multiple Myeloma

2023-05-18

Abstract excerpt

<h4>Background: </h4> Multiple myeloma (MM) is an incurable plasma cell malignancy, accounting for approximately 1% of all cancers. Despite recent advances in the treatment of MM, due to the introduction of proteasome inhibitors (PIs) such as bortezomib (BTZ) and carfilzomib (CFZ), relapses and disease progression remain common. Therefore, a major challenge is the development of novel therapeutic approaches to ove...

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Literature Corpus work: 2c0bc77d-8a33-5301-8708-f24a4770e8b1
DOI: 10.21203/rs.3.rs-2938292/v1

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