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Article

Identification of molecular vulnerabilities in human multiple myeloma cells by RNA interference lethality screening of the druggable genome.

Cancer research - 1 Feb 2012

Tiedemann Rodger E, Zhu Yuan Xao, Schmidt Jessica, Shi Chang Xin, Sereduk Chris, Yin Hongwei, Mousses Spyro, Stewart A Keith

Abstract excerpt

Despite recent advances in targeted treatments for multiple myeloma, optimal molecular therapeutic targets have yet to be identified. To functionally identify critical molecular targets, we conducted a genome-scale lethality study in multiple myeloma cells using siRNAs. We validated the top 160 lethal hits with four siRNAs per gene in three multiple myeloma cell lines and two non-myeloma cell lines, cataloging a...

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Share to Cyclin-Dependent Kinases
Share to Genes, Lethal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methyltransferases

Share to Multiple Myeloma

Share to Myeloid Cell Leukemia Sequence 1 Protein

Share to Protein-Tyrosine Kinases

Share to Proto-Oncogene Proteins c-bcl-2

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Source

Open in PubMed Open full text

Identifiers

PMID: 22147262
DOI: 10.1158/0008-5472.CAN-11-2781
PMCID: PMC3622723

Genes

MCL1
CKAP5
RRM1
TNK2
USP8

Provenance

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